Smart manufacturing is entering a new era, powered by digital twins—virtual replicas of physical assets, processes, or entire factories. These advanced simulations allow manufacturers to monitor operations in real time, predict equipment failures, optimize production, and reduce costs.
As shown by Linknovate’s innovation intelligence data, digital twins in manufacturing are one of the fastest-growing R&D trends of this year. Companies worldwide are increasingly investing in this technology to improve efficiency, reduce downtime, and accelerate innovation cycles. Within the broader Industry 4.0 movement, digital twin applications stand out as one of the strongest trends set to transform smart manufacturing in the coming years.

In this article, we spotlight the Top 10 startups in digital twins for smart manufacturing, showcasing the innovators redefining how factories are designed, monitored, and optimized.
What Are Digital Twins?
A digital twin is a dynamic, real-time digital model of a physical object, machine, or process. Unlike static CAD models, digital twins continuously receive data from sensors, IoT devices, and other sources, creating a “living” digital representation that evolves alongside its real-world counterpart.
Key Benefits of Digital Twins in Manufacturing
- Predictive Maintenance – Identifying potential equipment failures before they happen.
- Process Optimization – Streamlining workflows for maximum efficiency.
- Product Design & Testing – Simulating scenarios to reduce prototyping costs.
- Sustainability – Minimizing waste and energy usage through data-driven insights.
Digital twins are not just theoretical. They are already transforming industries like automotive, aerospace, energy, and pharmaceuticals. And the startups leading this charge are pushing the boundaries even further.
Top 10 Digital Twin Startups Transforming Smart Manufacturing
1. Akselos (Switzerland)
Akselos uses advanced simulation engines (finite-element analysis) to build twins of energy infrastructure—boosting design accuracy, maintenance, and lifecycle reliability.
2. Aiotel (India)
Aiotel combines AI and IoT with digital twin technology to provide real-time monitoring and predictive insights for connected assets. Its platform TWINVRSE creates dynamic simulations of physical systems, helping companies anticipate failures, reduce downtime, and optimize resource use.
3. Duality AI (USA)
Creators of the Falcon platform, Duality empowers manufacturers (and even smart city planners) with purpose-built digital twin simulations. They’ve partnered with Epic Games, AWS, and Autodesk to redefine virtual modeling.
4. Enreport (Finland)
Helsinki-based Enreport uses AI and digital twins to help organizations monitor and optimize energy consumption. By combining advanced modeling with real-time data, the company provides accurate simulations of energy performance, enabling businesses to cut costs, improve sustainability, and stay ahead of regulatory demands.

5. GC3 (Australia)
Founded in 2023, GC3 specializes in digital twin strategy consulting, helping organizations build internal capabilities to implement twinning solutions effectively across manufacturing processes.
6. Looq AI (USA)
Looq leverages AI-powered 3D capture hardware in an end-to-end platform, streamlining the mapping and twin creation of industrial infrastructure.
7. Multiverse Computing (Spain)
Based in the Basque Country, Multiverse has fused quantum-inspired algorithms with digital twin workflows. Their platform aids manufacturers like Bosch in accelerating simulations and improving defect detection.
8. Newtwen (Italy)
Newtwen develops AI-powered digital twins to simulate and predict the behavior of complex industrial systems. By combining advanced modeling with real-time data, its platform enables companies to optimize performance, extend equipment lifetime, and lower emissions.
9. Tomorrow Things (Germany)
Based in Bonn, Tomorrow Things is a startup at the intersection of generative AI and industrial engineering. The company specializes in accelerating the creation of digital twins by combining advanced AI techniques with industrial asset modeling. Their approach enables manufacturers and operators to build accurate, scalable, and cost-effective digital replicas of physical assets.
10. Twinsity (Germany)
This startup uses drone-captured 3D models to create digital twins, enabling detailed inspections and AI-assisted damage analysis, ideal for asset-intensive industries.
Future Outlook: The Road Ahead for Digital Twins in Manufacturing
As technologies like AI, quantum computing, AR/VR, and IIoT converge, digital twins will become even more powerful. Expect to see:
- Factory-wide twins simulating entire supply chains.
- AI-driven predictive twins that self-optimize.
- Sustainable manufacturing solutions reducing emissions and material waste.
Startups are at the heart of this revolution, and the ones highlighted here are shaping the next generation of smart manufacturing.
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